Semaglutide, is a hormone analogue that was indicated for use for diabetic patients. The National Institute for Health and Clinical Excellence (NICE) and the NHS have approved its use in weight loss and weight management in obese patients. In combination with an change in life style, Semaglutide helps a lot of patients to lose weight.
Semaglutide is a synthetic hormone analogue for the naturally occurring hormone Glucagon-Like Peptide-1 (GLP-1) which is produced by the small intestine in our bodies, from the name it functions as the hormone GLP-1. The three main actions of GLP-1 are the following:
- Delay gastric emptying and reduce small intestine motility
- Reduce appetite
- Increase pancreatic secretion of insulin hormone in response to glucose and, reduces the release of the hormone Glucagon which acts opposite to insulin, so basically the person becomes more “insulin sensitive”. Insulin resistance is one of the main problems for obese people to lose weight.